metropolis meaning, definition, what is metropolis: a very large city, often the most important city in a large area or country. Learn more. The definition of a metropolis is a large or main city. An example of a metropolis is Manhattan, New York. YourDictionary definition and usage example. A metropolis is a large city or conurbation which is a significant economic, political, and cultural center for a country or region, and an important hub for regional or international connections, commerce, and communications. The term is Greek (Greek: Μητρόπολη) and means the "mother city" of a History · Etymology and modern usage · Global city · Africa.